diff --git a/drivers/i2c/busses/i2c-ismt.c b/drivers/i2c/busses/i2c-ismt.c
index 8ed79a086f8580..1672effbcebb23 100644
--- a/drivers/i2c/busses/i2c-ismt.c
+++ b/drivers/i2c/busses/i2c-ismt.c
@@ -393,6 +393,9 @@ static int ismt_access(struct i2c_adapter *adap, u16 addr,
 
 	desc = &priv->hw[priv->head];
 
+	/* Initialize the DMA buffer */
+	memset(priv->dma_buffer, 0, sizeof(priv->dma_buffer));
+
 	/* Initialize the descriptor */
 	memset(desc, 0, sizeof(struct ismt_desc));
 	desc->tgtaddr_rw = ISMT_DESC_ADDR_RW(addr, read_write);